Yan Guo Study Reveals High Rate of PrEP Discontinuation

High Rate of PrEP Discontinuation Among Sexual and Gender-Minority Individuals

On Thursday, March 14, 2024, a study published in the esteemed journal Health Affairs shed light on the concerning issue of preexposure prophylaxis (PrEP) discontinuation among sexual and gender-minority individuals. The research, conducted by Yan Guo, Ph.D., from the City University of New York, revealed that the annual rate of discontinuation among this demographic ranged between 35 and 40 percent.

Study Details and Findings

In a comprehensive four-year national cohort study, researchers analysed the patterns of PrEP discontinuation among sexual and gender-minority individuals who had initiated the medication. The results were alarming, showing a high annual rate of discontinuation, with housing instability and a history of previous PrEP discontinuation emerging as significant predictors of this trend. Conversely, older age, clinical indication for PrEP, and possession of health insurance were linked to sustained PrEP use.

Call for Immediate Action

The authors of the study emphasised the urgent need for interventions to improve PrEP initiation, adherence, and long-term retention in care. They highlighted the importance of PrEP implementation programs and healthcare providers in identifying risk factors for discontinuation, such as prior instances of discontinuation, social determinants of health like housing instability and lack of health insurance, and younger age.

Implications and Recommendations

The findings of this study have significant implications for public health strategies aimed at reducing the spread of HIV among sexual and gender-minority populations. It is crucial for healthcare professionals and policymakers to address the barriers to PrEP continuation and provide tailored support to individuals at risk of discontinuation. By implementing targeted interventions and support systems, it is possible to enhance the effectiveness of PrEP in preventing HIV transmission.

For more information, the full study can be accessed through the Health Affairs website.